From Washington, Richmond, and Points North
1) Take I-85 South towards Durham
2) Just after the Guess Road and then Hillandale Road exits is an exit on the left for 15-501 South (EXIT 174-B). Take that exit.
3) Follow that ~ 4 miles, then bear to the right, following 15-501 towards Chapel Hill.
4) After about a dozen traffic lights, be on the lookout for a fork off to the right for Franklin Street / Downtown Chapel Hill. The fork should be ~ 2 miles after you cross over Interstate 40.
5) Once on Franklin Street, follow it for 4 miles up into and then through the center of town. Franklin will become Main Street after a sharp curve to the right and back left. You'll see a KFC on the right, and Cat's Cradle will be on the left about 1/2 block later. If you reach the Railroad tracks, you've gone too far.

From Raleigh, Greenville, Wilmington, and Points East / South
1) Take I-40 West, exiting for Route 15-501 (Exit 270).
2) At the top of the ramp, make a left heading South towards Chapel Hill.
3) Split-off exit for Franklin Street should be no more than 2 miles on the right after that turn.
4) Once on Franklin Street, follow it for 4 miles up into and then through the center of town. Franklin will become Main Street after a sharp curve to the right and back left. You'll see a KFC on the right, and Cat's Cradle will be on the left about 1/2 block later. If you reach the Railroad tracks, you've gone too far.

Lodging info
Red Roof Inn: 919 489 9421 (Located on 15-501 -- Follow directions from North)
University Inn (Best Western): 919 932 3000 (Located on NC 54)
Holiday Inn: 919 929 2171 (located on 15-501 -- Follow directions from North)